Abstract The Wilms' tumor 1 (WT1) gene encodes a transcription factor important for normal
cellular development and cell survival. The initial discovery of WT1 as the causative gene in …

Abstract Wilms tumor 1 (WT1) has long been implicated in acute myeloid leukemia. It has
been described to be both overexpressed and mutated in different forms of acute myeloid …

There is much interest in the mechanisms that regulate adult tissue homeostasis and their
relationship to processes governing foetal development. Mice deleted for the Wilms' tumour …

Molecular mechanisms for the developmental stage and tissue-specific regulation of the
erythropoietin (EPO) gene are poorly understood. Recent findings indicate a role of the …

The Wilms' tumor suppressor gene 1 (Wt1) is critically involved in a number of
developmental processes in vertebrates, including cell differentiation, control of the …

Angiotensin-converting enzyme (ACE) is best known for the catalytic conversion of
angiotensin I to angiotensin II. However, the use of gene-targeting techniques has led to …

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Mutations in the Wilms tumor suppressor 1 (WT1) gene are as frequent in acute myeloid
leukemia (AML) as in nephroblastma and predict poor prognosis. However, the role of WT1 …

The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-
expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid …

ABSTRACT The Wilms' tumor protein Wt1 is required for embryonic development and has
been implicated in hematologic disorders. Since Wt1 deficiency may compromise the …