[HTML][HTML] Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease
G Marucci, M Buccioni, D Dal Ben, C Lambertucci… - …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …
characterized by a progressive decline of cognitive functions accompanied by behavioral …
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease
Increased dietary intake of niacin has been correlated with reduced risk of Alzheimer's
disease (AD). Niacin serves as a high-affinity ligand for the receptor HCAR2 (GPR109A). In …
disease (AD). Niacin serves as a high-affinity ligand for the receptor HCAR2 (GPR109A). In …
Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions
A Dey, R Bhattacharya, A Mukherjee… - Biotechnology advances, 2017 - Elsevier
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …
associated with memory and cognition impairment ultimately leading to death. It is the …
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to
brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ) …
brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ) …
[HTML][HTML] Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis
ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
[HTML][HTML] Gamma oscillations in Alzheimer's disease and their potential therapeutic role
A Traikapi, N Konstantinou - Frontiers in systems neuroscience, 2021 - frontiersin.org
Despite decades of research, Alzheimer's Disease (AD) remains a lethal neurodegenerative
disorder for which there are no effective treatments. This review examines the latest …
disorder for which there are no effective treatments. This review examines the latest …
[HTML][HTML] Role of plant derived alkaloids and their mechanism in neurodegenerative disorders
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …
of neurons. Conventional as well as newer molecules have been tested but they offer just …
Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments
TP O'Leary, RE Brown - Genes, Brain and Behavior, 2022 - Wiley Online Library
The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …
Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood–brain barrier and inhibitors of β-amyloid
The blood–brain barrier (BBB) is a main obstacle for drug delivery targeting the central
nervous system (CNS) and treating Alzheimer's disease (AD). In order to enhance the …
nervous system (CNS) and treating Alzheimer's disease (AD). In order to enhance the …