[HTML][HTML] Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

TG Krieger, S Le Blanc, J Jabs, FW Ten… - Nature …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …

[HTML][HTML] Topological identification and interpretation for single-cell gene regulation elucidation across multiple platforms using scMGCA

Z Yu, Y Su, Y Lu, Y Yang, F Wang, S Zhang… - Nature …, 2023 - nature.com
Single-cell RNA sequencing provides high-throughput gene expression information to
explore cellular heterogeneity at the individual cell level. A major challenge in characterizing …

Robust identification of common genomic biomarkers from multiple gene expression profiles for the prognosis, diagnosis, and therapies of pancreatic cancer

MB Hossen, MA Islam, MS Reza, MK Kibria… - Computers in Biology …, 2023 - Elsevier
Pancreatic cancer (PC) is one of the leading causes of cancer-related death globally. So,
identification of potential molecular signatures is required for diagnosis, prognosis, and …

Identification of key gene targets for sensitizing colorectal cancer to chemoradiation: an integrative network analysis on multiple transcriptomics data

H Manoochehri, A Jalali, H Tanzadehpanah… - Journal of …, 2022 - Springer
Purpose Colorectal cancer (CRC) is a main cause of morbidity and mortality in the world.
Chemoradioresistance is a major problem in CRC treatment. Identification of novel …

[HTML][HTML] Combined analyses of RNA-sequence and Hi-C along with GWAS loci—A novel approach to dissect keloid disorder genetic mechanism

J Huang, X Zhou, W Wang, G Zhou, WJ Zhang… - PLoS …, 2022 - journals.plos.org
Keloid disorder is a tumour-like disease with invasive growth and a high recurrence rate.
Genetic contribution is well expected due to the presence of autosomal dominant …

Gene expression network analysis of precursor lesions in familial pancreatic cancer

M Tan, OB Schaffalitzky de Muckadell… - Journal of Pancreatic …, 2020 - liebertpub.com
Purpose: High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive
premalignant lesions, associated with risk of progression to pancreatic ductal …

Multi-modal domain adaptation for revealing spatial functional landscape from spatially resolved transcriptomics

L Wang, Y Hu, K Xiao, C Zhang, Q Shi… - Briefings in …, 2024 - academic.oup.com
Spatially resolved transcriptomics (SRT) has emerged as a powerful tool for investigating
gene expression in spatial contexts, providing insights into the molecular mechanisms …

Expression profiling and function analysis identified new microRNAs regulating cumulus expansion and apoptosis in cumulus cells

X Han, M Zhang, HJ Yuan, GL Wang… - Molecular Human …, 2022 - academic.oup.com
Although microRNAs (miRNAs) expressed in cumulus cells (CCs) may be used to select
competent oocytes/embryos, only a limited number of such miRNAs has been reported. To …

[HTML][HTML] Positive crosstalk between Hedgehog and NF-κB pathways is dependent on KRAS mutation in pancreatic ductal adenocarcinoma

Y Wang, D Wang, Y Dai, X Kong, X Zhu, Y Fan… - Frontiers in …, 2021 - frontiersin.org
It has been shown that aberrant activation of the Hedgehog (Hh) and nuclear factor-kappa B
(NF-κB) signaling pathways plays an important role in the pancreatic carcinogenesis, and …

PANK1 is a Prognostic Biomarker Associated with Immune Infiltration of Clear Cell Renal Carcinoma

B Ma, P Wang - Available at SSRN 3977791, 2021 - papers.ssrn.com
Background: PANK1 is expressed in some cancer types, but its role in clear cell renal
carcinoma (ccRCC) is unclear. We aimed to demonstrate the relationship between PANK1 …