[HTML][HTML] Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
TG Krieger, S Le Blanc, J Jabs, FW Ten… - Nature …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …
[HTML][HTML] Topological identification and interpretation for single-cell gene regulation elucidation across multiple platforms using scMGCA
Single-cell RNA sequencing provides high-throughput gene expression information to
explore cellular heterogeneity at the individual cell level. A major challenge in characterizing …
explore cellular heterogeneity at the individual cell level. A major challenge in characterizing …
Robust identification of common genomic biomarkers from multiple gene expression profiles for the prognosis, diagnosis, and therapies of pancreatic cancer
Pancreatic cancer (PC) is one of the leading causes of cancer-related death globally. So,
identification of potential molecular signatures is required for diagnosis, prognosis, and …
identification of potential molecular signatures is required for diagnosis, prognosis, and …
Identification of key gene targets for sensitizing colorectal cancer to chemoradiation: an integrative network analysis on multiple transcriptomics data
H Manoochehri, A Jalali, H Tanzadehpanah… - Journal of …, 2022 - Springer
Purpose Colorectal cancer (CRC) is a main cause of morbidity and mortality in the world.
Chemoradioresistance is a major problem in CRC treatment. Identification of novel …
Chemoradioresistance is a major problem in CRC treatment. Identification of novel …
[HTML][HTML] Combined analyses of RNA-sequence and Hi-C along with GWAS loci—A novel approach to dissect keloid disorder genetic mechanism
J Huang, X Zhou, W Wang, G Zhou, WJ Zhang… - PLoS …, 2022 - journals.plos.org
Keloid disorder is a tumour-like disease with invasive growth and a high recurrence rate.
Genetic contribution is well expected due to the presence of autosomal dominant …
Genetic contribution is well expected due to the presence of autosomal dominant …
Gene expression network analysis of precursor lesions in familial pancreatic cancer
M Tan, OB Schaffalitzky de Muckadell… - Journal of Pancreatic …, 2020 - liebertpub.com
Purpose: High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive
premalignant lesions, associated with risk of progression to pancreatic ductal …
premalignant lesions, associated with risk of progression to pancreatic ductal …
Multi-modal domain adaptation for revealing spatial functional landscape from spatially resolved transcriptomics
Spatially resolved transcriptomics (SRT) has emerged as a powerful tool for investigating
gene expression in spatial contexts, providing insights into the molecular mechanisms …
gene expression in spatial contexts, providing insights into the molecular mechanisms …
Expression profiling and function analysis identified new microRNAs regulating cumulus expansion and apoptosis in cumulus cells
X Han, M Zhang, HJ Yuan, GL Wang… - Molecular Human …, 2022 - academic.oup.com
Although microRNAs (miRNAs) expressed in cumulus cells (CCs) may be used to select
competent oocytes/embryos, only a limited number of such miRNAs has been reported. To …
competent oocytes/embryos, only a limited number of such miRNAs has been reported. To …
[HTML][HTML] Positive crosstalk between Hedgehog and NF-κB pathways is dependent on KRAS mutation in pancreatic ductal adenocarcinoma
Y Wang, D Wang, Y Dai, X Kong, X Zhu, Y Fan… - Frontiers in …, 2021 - frontiersin.org
It has been shown that aberrant activation of the Hedgehog (Hh) and nuclear factor-kappa B
(NF-κB) signaling pathways plays an important role in the pancreatic carcinogenesis, and …
(NF-κB) signaling pathways plays an important role in the pancreatic carcinogenesis, and …
PANK1 is a Prognostic Biomarker Associated with Immune Infiltration of Clear Cell Renal Carcinoma
B Ma, P Wang - Available at SSRN 3977791, 2021 - papers.ssrn.com
Background: PANK1 is expressed in some cancer types, but its role in clear cell renal
carcinoma (ccRCC) is unclear. We aimed to demonstrate the relationship between PANK1 …
carcinoma (ccRCC) is unclear. We aimed to demonstrate the relationship between PANK1 …