[HTML][HTML] The biological and clinical aspects of a latent tuberculosis infection

NF Khabibullina, DM Kutuzova, IA Burmistrova… - Tropical medicine and …, 2022 - mdpi.com
Tuberculosis (TB), caused by bacilli from the Mycobacterium tuberculosis complex, remains
a serious global public health problem, representing one of the main causes of death from …

[HTML][HTML] Contribution and future of high-throughput transcriptomics in battling tuberculosis

A Martínez-Pérez, O Estévez… - Frontiers in …, 2022 - frontiersin.org
While Tuberculosis (TB) infection remains a serious challenge worldwide, big data and
“omic” approaches have greatly contributed to the understanding of the disease …

Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort

U Banerjee, S Chunchanur, KN Balaji, A Singh… - Genes & …, 2023 - nature.com
Host immune response to COVID-19 plays a significant role in regulating disease severity.
Although big data analysis has provided significant insights into the host biology of COVID …

[HTML][HTML] Exploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosis

MF Khan, A Ali, HM Rehman, S Noor Khan… - Scientific Reports, 2024 - nature.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis, ranks among the top causes of
global human mortality, as reported by the World Health Organization's 2022 TB report. The …

The significance of persisters in tuberculosis drug discovery: Exploring the potential of targeting the glyoxylate shunt pathway

A Negi, R Sharma - European Journal of Medicinal Chemistry, 2023 - Elsevier
The significant challenge in confronting TB eradication is the discursive treatment that
results in the disease reactivation, patient non compliance and drug resistance. The …

Latent tuberculosis and computational biology: A less-talked affair

DT Sarmah, R Parveen, J Kundu… - Progress in Biophysics and …, 2023 - Elsevier
Tuberculosis (TB) is a pervasive and devastating air-borne disease caused by the
organisms belonging to the Mycobacterium tuberculosis (Mtb) complex. Currently, it is the …

PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations in Mycobacterium tuberculosis

U Banerjee, A Chedere, R Padaki… - Journal of Chemical …, 2023 - ACS Publications
Mining large-scale data to discover biologically relevant information remains a challenge
despite the rapid development of bioinformatics tools. Here, we have developed a new tool …

Inhibition of leukotriene‐B4 signalling‐mediated host response to tuberculosis is a potential mode of adjunctive host‐directed therapy

U Banerjee, SM Borbora, M Guha, V Yadav… - …, 2024 - Wiley Online Library
Abstract Treatment of tuberculosis (TB) is faced with several challenges including the long
treatment duration, drug toxicity and tissue pathology. Host‐directed therapy provides …

Evaluation of a novel inhibitor of aspartate semialdehyde dehydrogenase as a potent antitubercular agent against Mycobacterium tuberculosis

R Yang, W Cao, S Liu, Q Li, Y Sun, C Liang… - The Journal of …, 2022 - nature.com
The in vitro activity of IMB-XMA0038, a novel inhibitor targeting Mycobacterial tuberculosis
(Mtb) aspartate semialdehyde dehydrogenase, was evaluated. Minimum inhibitory …

[HTML][HTML] Protein Integrated Network Analysis to Reveal Potential Drug Targets Against Extended Drug-Resistant Mycobacterium tuberculosis XDR1219

NUA Zahra, F Jamil, R Uddin - Molecular Biotechnology, 2021 - Springer
The reconstruction and analysis of the protein–protein interaction (PPI) network is a powerful
approach to understand the complex biological and molecular functions in normal and …