Genomic imprinting refers to the parent-of-origin expression of genes, which originates from
epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a …

Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late
pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted …

Nutrient intake is obligatory for animal growth and development, but nutrients alone are not
sufficient. Indeed, insulin and homologous hormones are required for normal growth even in …

The metabolic health trajectory of an individual is shaped as early as prepregnancy, during
pregnancy, and lactation period. Both maternal nutrition and metabolic health status are …

Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has
different binding properties on two IR isoforms, mimicking insulin's function. However, the …

When, in 1754, John Hunter demonstrated unequivocally that the maternal and fetal
circulations are separated during pregnancy, the placenta became considered a barrier …

In this work, the morphogenesis mechanisms are considered from the complexity
perspective. It is shown that both morphogenesis and the functioning of organs should be …

Reduced insulin sensitivity (or greater insulin resistance) is a hallmark of normal physiology
in late pregnancy and also underlies gestational diabetes mellitus (GDM) pathophysiology …

Proteins secreted from maternal, fetal, and placental tissue are vital for processes like
placental development, immunotolerance, and fetal growth, and are associated with …

The yolk sac stores a large amount of maternal material accumulated during 41 oogenesis,
and serves as a source of nutrients for embryonic development in 42 both viviparous and …