Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco
alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas …

There are three major epithelial types in the nasal mucosa, in addition to numerous
accessory structures, some of which are species specific. Without careful and consistent …

The largest collection of basic, clinical, and applied knowledge on the chemical senses ever
compiled in one volume, the third edition of Handbook of Olfaction and Gustation …

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology …

The relationship between the formation of O 6-methylguanine (O6MG) and the induction of
lung, liver, and nasal tumors in the Fischer 344 rat by the tobacco-specific nitrosamine 4 …

Knowledge of patterns of lesion distribution can provide insight into the relative roles played
by regional tissue dose and local tissue susceptibility in toxic responses to xenobiotics in the …

Scientists and decision makers from all sectors agree that risk assessments should be
based on the best available science. Several years ago, the Health and Environmental …

The rationale for using animal models to estimate the tumorigenic potential of
chemicalcarcinogens in humans has been based on interspecies similarities. An extensive …

Although many questions remain unanswered, the general principle of the sequence of
events leading to cancer after exposure to genotoxic carcinogens has become increasingly …

The nasal passages of laboratory animals and man are complex, and lesions induced in the
delicate nasal lining by inhaled air pollutants vary considerably in location and nature. The …