Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

It has been recently recognized that the tumor microenvironment (TME) is an essential factor
that defines the efficiency of chemotherapy. The local TME, consisting of immune cells with …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

Glioblastoma is one of the most fatal cancers, characterized by a strong vascularized
phenotype. YKL-40, a secreted glycoprotein, is overexpressed in patients with glioblastomas …

Tumor angiogenesis is of paramount importance in solid tumor development. Elevated
serum levels of YKL-40, which is a secreted heparin-binding glycoprotein, have been …

YKL-40, a member of the “mammalian chitinase–like proteins,” is expressed and secreted by
several types of solid tumors. The exact function of YKL-40 in cancer diseases is unknown …

Abstract Background CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory
conditions and cancers. We have previously reported elevated CHI3L1 concentration in the …

Substantial evidence supports a role of chronic subclinical inflammation and activation of the
innate immune system in the pathogenesis of insulin resistance and endothelial dysfunction …

Numerous inflammatory conditions are associated with elevated YKL‐40 expression by
infiltrating macrophages. Thus, we were surprised to observe minimal macrophage and …

Expression of the chitinase 3-like protein HC-gp39 (human cartilage glycoprotein 39) is
associated with conditions of increased matrix turnover and tissue remodelling. High levels …