Excessive reactive oxygen species Revised abstract, especially superoxide anion (O2•−),
play important roles in the pathogenesis of many cardiovascular diseases, including …

Cardiac autonomic neuropathy (CAN) is an often overlooked and common complication of
diabetes mellitus. CAN is associated with increased cardiovascular morbidity and mortality …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

The structural and functional integrity of the brain depends on the delicate balance between
substrate delivery through blood flow and energy demands imposed by neural activity …

Cardiovascular complications, characterized by endothelial dysfunction and accelerated
atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic
complications. However, intervention studies with classic antioxidants, such as vitamin E …

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR
FUNCTION - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative
stress that contributes to the pathogenesis of this debilitating disease. This has prompted …

Cardiac autonomic neuropathy (CAN) is a common and often-underdiagnosed complication
of diabetes mellitus (DM). CAN is associated with increased mortality, cardiovascular …