Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

Lung cancer is the number one cause of cancer-related deaths worldwide. DNA methylation
is an epigenetic mechanism that regulates gene expression, and disease-specific …

General DNA hypomethylation is associated with Alzheimer's disease (AD), but it is unclear
when DNA hypomethylation starts or plays a role in AD pathology or whether DNA re …

Alzheimer's disease (AD) remains one of the most formidable neurological disorders,
affecting millions globally. This review provides a holistic overview of the therapeutic …

The relationship between long-term cholinergic dysfunction and risk of developing dementia
is poorly understood. Here we used mice with deletion of the vesicular acetylcholine …

Altered epigenetic mechanisms are implicated in the cognitive decline associated with
neurodegenerative diseases such as in Alzheimer's disease (AD). AD is the most prevalent …

Both aging and Alzheimer's disease (AD) are associated with widespread epigenetic
changes, with most evidence suggesting global hypomethylation in AD. It is, however …

Cytosine methylation in DNA constitutes an important epigenetic layer of transcriptional and
regulatory control in many eukaryotes. Profiling DNA methylation across the genome is …

Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting millions of
people worldwide. While a number of studies have focused on identifying genetic variants …