Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …

Background Available therapies for myelofibrosis can exacerbate cytopenias and are not
indicated for patients with severe thrombocytopenia. Pacritinib, which inhibits both JAK2 and …

Sickle cell disease is a common and life-threatening haematological disorder that affects
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …

Several forms of hair loss in humans are characterized by the inability of hair follicles to
enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase …

Abstract Background The Philadelphia chromosome− negative myeloproliferative
neoplasms (MPN) myelofibrosis (MF), polycythemia vera (PV), and essential …

Abstract Myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET)
are myeloproliferative neoplasms (MPNs) associated with high disease burden, reduced …

Major progress has been recently made in understanding the molecular pathogenesis of
myeloproliferative neoplasms (MPN). Mutations in one of four genes—JAK2, MPL, CALR …

Interferon alpha (IFN-α) has been used for over 30 years to treat myeloproliferative
neoplasms (MPNs). IFN-α was shown to induce clinical, hematological, molecular and …