Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Background: Travelers' diarrhea causes significant morbidity including some sequelae, lost
travel time and opportunity cost to both travelers and countries receiving travelers. Effective …

Carbapenemases increasingly have been reported in Enterobacteriaceae in the past 10
years. Klebsiella pneumoniae carbapenemases have been reported in the United States …

Bacterial infections are frequent in cirrhotic patients with acute decompensation or acute-on-
chronic liver failure and can complicate the clinical course. Delayed diagnosis and …

β-Lactamase evolution presents to the infectious disease community a major challenge in
the treatment of infections caused by multidrug-resistant gram-negative bacteria. Because …

The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged
both the scientific and pharmaceutical sectors. The hallmark of this general increase is the …

Infection due to Acinetobacter baumannii has become a significant challenge to modern
healthcare systems. The organism shows a formidable capacity to develop antimicrobial …

Extended-spectrum β-lactamases (ESBLs), which hydrolyse extended-spectrum
cephalosporins and are inhibited by clavulanic acid, are spreading among …

Previous studies of antibiotic resistance dissemination by travel have, by targeting only a
select number of cultivable bacterial species, omitted most of the human microbiome. Here …