One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

The corticospinal tract (CST) is the most important motor system in humans, yet robust
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In …

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the
lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal
regeneration and functional plasticity. It is well established that an upregulation of glial …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Animal studies are now showing the exciting potential to achieve significant functional
recovery following central nervous system (CNS) injury by manipulating both the inefficient …