NNRTI and liver damage: evidence of their association and the mechanisms involved

AM Benedicto, I Fuster-Martínez, J Tosca… - Cells, 2021 - mdpi.com
Due to the improved effectiveness and safety of combined antiretroviral therapy, human
immunodeficiency virus (HIV) infection has become a manageable, chronic condition rather …

The Hepatoprotective Effects of Moringa oleifera against Antiretroviral-Induced Cytotoxicity in HepG2 Cells: A Review

M Saki, H De Villiers, C Ntsapi, C Tiloke - Plants, 2023 - mdpi.com
The untreated human immunodeficiency virus (HIV), a lentivirus species that attacks immune
cells (CD4+ T cells), causes acquired immunodeficiency syndrome (AIDS). HIV-positive …

[HTML][HTML] Cathelicidins and defensins antimicrobial host defense peptides in the treatment of TB and HIV: Pharmacogenomic and nanomedicine approaches towards …

PN Dlozi, A Gladchuk, RD Crutchley, N Keuler… - Biomedicine & …, 2022 - Elsevier
Tuberculosis (TB) and human immunodeficiency virus (HIV) represent a significant burden
of disease on a global scale. Despite improvements in the global epidemic status, largely …

In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay

T Brecklinghaus, W Albrecht, J Duda, F Kappenberg… - Toxicology Letters, 2022 - Elsevier
The accumulation of lipid droplets in hepatocytes is a key feature of drug-induced liver injury
(DILI) and can be induced by a subset of hepatotoxic compounds. In the present study, we …

Apoptosis of hepatocytes: relevance for HIV-infected patients under treatment

A Gruevska, ÁB Moragrega, A Cossarizza… - Cells, 2021 - mdpi.com
Due to medical advances over the past few decades, human immunodeficiency virus (HIV)
infection, once a devastatingly mortal pandemic, has become a manageable chronic …

Prevalence of non-alcoholic fatty liver disease in a multicentre cohort of people living with HIV in Spain.

J Navarro, A Curran, B Raventós, J García… - European Journal of …, 2023 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is one of the most important liver
comorbidities in people living with HIV (PLWH). Factors that could lead to a higher …

Prevalence of nonalcoholic fatty liver disease using noninvasive techniques among children, adolescents, and youths living with HIV

I Carrasco, A Olveira, Á Lancharro, L Escosa… - AIDS, 2022 - journals.lww.com
Objective: The prevalence of subclinical liver abnormalities is high among people with HIV,
but data regarding perinatally HIV-infected children and adolescents (PHIV) are scarce …

Water-Based Epidemiological Investigation of Hepatitis E Virus in South Africa

K Salemane, LZ Coetzee, G Pocock, B Genthe… - Food and Environmental …, 2024 - Springer
Hepatitis E virus (HEV) is an emerging zoonotic pathogen that exhibits great host diversity.
The primary means of transmission of the virus in low-and middle-income countries is …

Traditional Chinese Medicine for HIV‐Associated Acute Herpes Zoster: A Systematic Review and Meta‐Analysis of Randomized Trials

Y Jiang, RX Zheng, ZY Yu, XW Zhang… - Evidence‐Based …, 2022 - Wiley Online Library
Background. Herpes zoster (HZ) is a common infection in individuals with acquired
immunodeficiency syndrome (AIDS) patients. Traditional Chinese medicine (TCM) has been …

[HTML][HTML] Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A …

N Pourmohamadi, MPA Toutkaboni… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Background: Anti-tuberculosis drug-induced hepatotoxicity can result from genetic
polymorphism of the isoniazid (INH) metabolizing enzyme. This study aimed to determine …