Bruton's tyrosine kinase (BTK) is an essential component of multiple signaling pathways that
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …

Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …

The two major subtypes of diffuse large B cell lymphoma (DLBCL)—activated B cell–like
(ABC) and germinal center B cell–like (GCB)—arise by distinct mechanisms, with ABC …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Despite the development of novel targeted drugs, the molecular heterogeneity of diffuse
large B-cell lymphoma (DLBCL) still poses a substantial therapeutic challenge. DLBCL can …

The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

Based on the clinical features of myeloma and related malignancies of plasma cells, it has
been possible to generate a model system of myeloma progression from a normal plasma …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …