Background and Objective Atrial fibrillation (AF), the most common cardiac arrhythmia,
typically increases with age. Oral anticoagulants (OACs) are the cornerstone of treatment to …

The prevalence of atrial fibrillation (AF) is increasing as the population ages. AF treatment-
related complications also increase markedly in older adults (defined as≥ 75 years of age …

Background and purpose Dementia is one of the most common disorders and is associated
with increased morbidity, mortality and decreased quality of life. The present guideline …

Objective Direct oral anticoagulants have been evaluated in the general population, but
proper evidence for their safe use in the geriatric population is still missing. We compared …

Atrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent conditions
with a significant healthcare burden, and represent the main indications for anticoagulation …

Importance Contemporary national clinical practice guidelines recommend direct-acting oral
anticoagulants (DOACs) as the first-line anticoagulant strategy over warfarin for most …

Importance Current guidelines recommend direct oral anticoagulants (DOACs) over warfarin
for stroke prevention in patients with atrial fibrillation (AF) who are at high risk. Despite …

Direct-acting oral anticoagulants (DOACs) are replacing conventional VKA (vitamin K
antagonist, ie, warfarin) for various indications where a therapeutic anticoagulant effect is …

Aims The aim of the present meta-analysis was to evaluate the efficacy and safety of non-
vitamin K oral antagonists (NOACs) vs. vitamin K antagonists (VKAs) in elderly patients with …

Background Frailty is common in older patients with atrial fibrillation (AF). Current guidelines
recommend oral anticoagulant therapy (OAT) except in case of severe frailty or reduced life …