The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …

Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …

Abstract Runt-related transcription factor-1 (RUNX1), also known as acute myeloid
leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription …

Aging of the heart is associated with a blunted response to sympathetic stimulation, reduced
contractility, and increased propensity for arrhythmias, with the risk of sudden cardiac death …

Cardiovascular diseases (CVDs) and complications are often seen in patients with prostate
cancer (PCa) and affect their clinical management. Despite acceptable safety profiles and …

The dilemma of how to categorize and classify diseases has been debated for centuries.
The field of medical genetics has historically approached nosology based on clinical …

Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Background: Myocardial infarction (MI) is a leading cause of heart failure and death
worldwide. Preservation of contractile function and protection against adverse changes in …

The sarco/endoplasmic reticulum Ca-ATPase (SERCA) is a P-type ion pump that transports
Ca2+ from the cytosol into the endoplasmic/sarcoplasmic reticulum (ER/SR) in most …

This overview gives an update on the molecular mechanisms, clinical manifestations,
diagnosis and therapy of arrhythmogenic cardiomyopathy (ACM). ACM is mostly hereditary …