Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and
metaplasia result in changes in stored and secreted mucin and the production of a …

Most patients diagnosed with chronic obstructive pulmonary disease (COPD) present with
hallmark features of airway mucus hypersecretion, including cough and expectoration …

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …

Cystic fibrosis (CF) lung disease is characterized by early and persistent mucus
accumulation and neutrophilic inflammation in the distal airways. Identification of the factors …

Using a therapeutic strategy that is free from traditional diagnostic labels and based on the
identification of “treatable traits”(TTs), which are influential in clinical presentations in each …

Goblet cell metaplasia, a disabling hallmark of chronic lung disease, lacks curative
treatments at present. To identify novel therapeutic targets for goblet cell metaplasia, we …

A spectrum of intrapulmonary airway diseases, for example, cigarette smoke–induced
bronchitis, cystic fibrosis, primary ciliary dyskinesia, and non–cystic fibrosis bronchiectasis …

Forkhead box (FOX) proteins are transcriptional factors that regulate various cellular
processes. This minireview provides an overview of FOXA2 functions, with a special …

Inorganic polyphosphate (polyP) is a widely distributed polymer found from bacteria to
animals, including marine species. This polymer exhibits morphogenetic as well as antiviral …

Human rhinoviruses (HRVs) are associated with acute exacerbations in patients with
chronic obstructive pulmonary disease (COPD) and asthma, which are accompanied by …