Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections
U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …
and artificial intelligence provide new opportunities for target-based antibacterial drug …
[HTML][HTML] Role of dynamin-related protein 1-dependent mitochondrial fission in drug-induced toxicity
D Li, Y Li, W Pan, B Yang, C Fu - Pharmacological Research, 2024 - Elsevier
Abstract Dynamin-related protein 1 (DRP1) is an essential controller of mitochondrial fission
whose activity is tightly controlled to ensure balanced mitochondrial dynamics and maintain …
whose activity is tightly controlled to ensure balanced mitochondrial dynamics and maintain …
An integrated in vitro approach to identifying chemically induced oxidative stress and toxicity in mitochondria
D Kim, Y Shin, HS Kim, KH Park, ON Bae - Chemosphere, 2024 - Elsevier
Growing concerns exist about increasing chemical usage and the potential health risks.
Developing an efficient strategy to evaluate or predict the toxicity of chemicals is necessary …
Developing an efficient strategy to evaluate or predict the toxicity of chemicals is necessary …
Mitochondrial–Stem Cell Connection: Providing Additional Explanations for Understanding Cancer
P Martinez, I Baghli, G Gourjon, TN Seyfried - Metabolites, 2024 - mdpi.com
The cancer paradigm is generally based on the somatic mutation model, asserting that
cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) …
cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) …
Toxicity of Water-Soluble Dg-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro
S Prylutska, A Grebinyk, S Ponomarenko… - International Journal of …, 2024 - mdpi.com
The application of a biocompatible polymer nanocarrier can provide target delivery to tumor
tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed …
tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed …