PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders

A Topaloudi, P Jain, MB Martinez, JK Bryant… - Frontiers in …, 2023 - frontiersin.org
Introduction Autoimmune disorders (ADs) are a group of about 80 disorders that occur when
self-attacking autoantibodies are produced due to failure in the self-tolerance mechanisms …

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

J Sawaed, L Zelik, Y Levin, R Feeney, M Naama… - bioRxiv, 2024 - biorxiv.org
Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs
are characterized by a damaged mucus layer, which does not properly separate the host …

[图书][B] Targeting lymph node stromal cells to induce immune tolerance

FB Schälter - 2023 - search.proquest.com
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that leads to joint
inflammation and disability. Although research has advanced our understanding of RA, the …

A Sex-Specific Molecular and Behavioural Analysis of the Impacts of Obesogenic Diet Exposure and Probiotic Treatment: Insights Into Specific Nutritional …

E Myles - 2023 - dalspace.library.dal.ca
Nutrition-related environmental exposures (eg, diet ingredients, vitamins, probiotic strains)
have been reported to impact the composition of the gut microbiota, the microbiota …

Antimicrobial peptides and the skin and gut microbiomes

A Joseph, M Nuriel-Ohayon, S Bel, TA Harris - Peptide and Peptidomimetic …, 2022 - Elsevier
Animals are in constant contact with the microbial world. These interactions include fending
off potential pathogens and also maintaining a beneficial relationship with the microbiome …