Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
Can infections trigger alpha-synucleinopathies?
As synucleinopathies, Parkinson's disease (PD) and multiple system atrophy (MSA) are
neurodegenerative diseases that involve the spread of pathogenic alpha-synuclein (αSyn) …
neurodegenerative diseases that involve the spread of pathogenic alpha-synuclein (αSyn) …
The manifold roles of sphingolipids in viral infections
E Avota, J Bodem, J Chithelen, P Mandasari… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are essential components of eukaryotic cells. In this review, we want to
exemplarily illustrate what is known about the interactions of sphingolipids with various …
exemplarily illustrate what is known about the interactions of sphingolipids with various …
Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus
EB Vitner, H Achdout, R Avraham, B Politi… - Journal of Biological …, 2021 - ASBMB
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major threat to global health. Vaccines are ideal solutions …
coronavirus 2 (SARS-CoV-2), is a major threat to global health. Vaccines are ideal solutions …
Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion
Due to climate changes, there has been a large expansion of emerging tick-borne zoonotic
viruses, including Heartland bandavirus (HRTV) and Dabie bandavirus (DBV). As etiologic …
viruses, including Heartland bandavirus (HRTV) and Dabie bandavirus (DBV). As etiologic …
Depletion of host and viral sphingomyelin impairs influenza virus infection
Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as
well as periodic pandemics. A complete understanding of the virus pathogenesis and host …
well as periodic pandemics. A complete understanding of the virus pathogenesis and host …
The role of lipid metabolism in influenza A virus infection
Y Zhou, J Pu, Y Wu - Pathogens, 2021 - mdpi.com
Influenza A virus (IAV) is an important zoonotic pathogen that can cause disease in animals
such as poultry and pigs, and it can cause infection and even death in humans, posing a …
such as poultry and pigs, and it can cause infection and even death in humans, posing a …
Recent Progress in the Development of Opaganib for the Treatment of Covid-19
CD Smith, LW Maines, SN Keller… - Drug Design …, 2023 - Taylor & Francis
The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …
humanitarian and economic stress across the world. Although antivirals active against mild …
Targeting the complement–sphingolipid system in COVID-19 and gaucher diseases: evidence for a new treatment strategy
VS Trivedi, AF Magnusen, R Rani, L Marsili… - International Journal of …, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced disease
(COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its …
(COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its …