The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

The homeostatic blood protease, activated protein C (APC), can function as (1) an
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …

More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …

Background SARS-CoV-2 infection is associated with thrombotic and microvascular
complications. The cause of coagulopathy in the disease is incompletely understood …

Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular
receptor for protein C on endothelial cells. EPCR plays a crucial role in the protein C …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

Venous thromboembolism (VTE) is major health problem and is sometimes complicated by
lethal pulmonary embolism (PE). Disturbances of the coagulation and anticoagulation …

Significance: Burns are debilitating, life threatening, and difficult to assess and manage.
Recent advances in assessment and management have occurred since a comprehensive …

Endothelial cells express several types of integral membrane protein receptors, which upon
interaction and activation by their specific ligands, initiate a signalling network that links …