Background and Objectives Recent clinical data suggested that platelet materials used in
regenerative medicine exert anti‐inflammatory effects. One must understand whether …

Inflammation is a very complex reaction to infection or injury the endeavour being to contain
the infection and harm to a limited area. The process is associated with the activation of the …

2 Arterioscler Thromb Vasc Biol April 2018 ticagrelor was superior to clopidogrel in> 18 000
patients with ACS (either STEMI or non-STEMI) undergoing PCI who were treated with …

Thrombin is a pleiotropic enzyme that regulates hemostasis and nonhemostatic functions,
including an array of actions within and on the vasculature. Physiologically, thrombin …

Options for anticoagulation have been expanding steadily over the past few decades,
providing a greater number of agents for prevention and management of thromboembolic …

Essentials• Factor VIIa binds activated platelets to promote hemostasis in hemophilia
patients with inhibitors.• The interactions and sites responsible for platelet‐FVIIa binding are …

Objective—Histones are detrimental in late sepsis. Both activated protein C (aPC) and
heparin can reverse their effect. Here, we investigated whether histones can modulate aPC …

Crystal structures of factor (F) VIIa/soluble tissue factor (TF), obtained under high Mg2+
(50mM Mg2+/5mM Ca2+), have three of seven Ca2+ sites in the γ-carboxyglutamic acid …

Activated protein C (PC) is an anticoagulant involved in the interactions between the
coagulation and immune systems. Activated PC has broad anti-inflammatory effects that are …

Thrombin and activated protein C (aPC) bound to the endothelial protein C receptor (EPCR)
both activate protease-activated receptor 1 (PAR1) generating either harmful or protective …