Metabolic determinants of Alzheimer's disease: A focus on thermoregulation

M Tournissac, M Leclerc, J Valentin-Escalera… - Ageing Research …, 2021 - Elsevier
Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated
with central and peripheral metabolic anomalies, such as impaired glucose utilization and …

[HTML][HTML] Obesity and brain function: The brain–body crosstalk

SX Sui, JA Pasco - Medicina, 2020 - mdpi.com
Dementia comprises a wide range of progressive and acquired neurocognitive disorders.
Obesity, defined as excessive body fat tissue, is a common health issue world-wide and a …

Relationship between adipokines, cognition, and brain structures in old age depending on obesity

J Ha, S Kwak, KY Kim, H Kim, SY Cho… - The Journals of …, 2023 - academic.oup.com
Background Adipokines such as leptin and adiponectin are associated with cognitive
function. Although adiposity crucially affects adipokine levels, it remains unclear whether the …

Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats

Z Zhang, L Guo, F Yang, S Peng, D Wang… - ACS Chemical …, 2023 - ACS Publications
Perioperative neurocognitive disorder (PND) is a common adverse event after surgical
trauma in elderly patients. The pathogenesis of PND is still unclear. Adiponectin (APN) is a …

[HTML][HTML] MicroRNA: a linking between astrocyte dysfunction, mild cognitive impairment, and neurodegenerative diseases

AE Ramírez, N Gil-Jaramillo, MA Tapias… - Life, 2022 - mdpi.com
Simple Summary Neurodegenerative diseases are complex neurological disorders with a
high incidence worldwide in older people, increasing hospital visits and requiring expensive …

[HTML][HTML] Harnessing the power of Leptin: the biochemical link connecting obesity, diabetes, and cognitive decline

P Grasso - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
In this review, the current understanding of leptin's role in energy balance, glycemic
regulation, and cognitive function is examined, and its involvement in maintaining the …

Associations of Serum Insulin and Related Measures With Neuropathology and Cognition in Older Persons With and Without Diabetes

Z Arvanitakis, AW Capuano, H Tong… - Annals of …, 2024 - Wiley Online Library
Objective To examine associations of serum insulin and related measures with
neuropathology and cognition in older persons. Methods We studied 192 older persons (96 …

[HTML][HTML] Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia

A Arjunan, J Song - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Dementia is a detrimental neuropathologic condition with considerable physical, mental,
social, and financial impact on patients and society. Patients with metabolic syndrome …

Cancer‐related fatigue: Towards a more targeted approach based on classification by biomarkers and psychological factors

ME Schmidt, T Maurer, S Behrens… - … journal of cancer, 2024 - Wiley Online Library
Cancer‐related fatigue is a frequent, burdensome and often insufficiently treated symptom. A
more targeted treatment of fatigue is urgently needed. Therefore, we examined biomarkers …

An exploratory research report on brain mineralization in postoperative delirium and cognitive decline

F Lammers‐Lietz, F Borchers, I Feinkohl… - European Journal of …, 2024 - Wiley Online Library
Delirium is a severe postoperative complication associated with poor overall and especially
neurocognitive prognosis. Altered brain mineralization is found in neurodegenerative …