Decentralized clinical trials (DCTs) have the potential to improve accessibility, diversity, and
retention in clinical trials by moving trial activities to participants' homes and local …

Objective To determine the rate of early discontinuation and non-publication of randomised
controlled trials involving patients undergoing surgery. Design Cross sectional observational …

Background Randomised trials (also referred to as 'randomised controlled trials' or 'trials')
are the optimal way to minimise bias in evaluating the effects of competing treatments …

Randomized controlled trials (RCTs) can provide high quality evidence about the
comparative effectiveness of health care interventions, but many RCTs struggle with or fail to …

Background We previously found that 25% of 1,017 randomized clinical trials (RCTs)
approved between 2000 and 2003 were discontinued prematurely, and 44% remained …

Abstract Objectives Randomized clinical trials (RCTs) are costly. We aimed to provide a
systematic overview of the available evidence on resource use and costs for RCTs to …

Background Despite having many advantages, online eHealth trials are not without
challenges—notably, participant recruitment, and outcome data retention. Moreover …

Background Randomised controlled trials (RCTs) are essential for evidence-based
medicine and increasingly rely on front-line clinicians to recruit eligible patients. Clinicians' …

Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐
exome sequencing (WES) was carried out on patients from three different families that …

Background Poor participant recruitment is the most frequent reason for premature
discontinuation of randomized clinical trials (RCTs), particularly if they are investigator …