Objectives: To compare outcomes between hemiarthroplasty (HA) and reversed shoulder
arthroplasty (RSA) as a treatment for dislocated 3-part and 4-part proximal humerus …

Background Research has revealed that manifest Alzheimer's disease (AD) dementia is
preceded by preclinical and prodromal phases during which pathology is accumulating but …

Background Many randomised controlled trials (RCTs) struggle to recruit, despite valiant
efforts. The QRI (QuinteT Recruitment Intervention) uses innovative research methods to …

Background Depression and anxiety are common mental health conditions in college and
university student populations. Offering transdiagnostic, web-based prevention programs …

Importance To our knowledge, there are no published randomized clinical trials of
recruitment strategies. Rigorously evaluated successful recruitment strategies for children …

BACKGROUND: Extravasation injuries are caused by unintended leakages of fluids or
medicines from intravenous lines, but there is no consensus on the best treatment …

Objective: To investigate the prevalence of discontinuation and nonpublication of surgical
versus medical randomized controlled trials (RCTs) and to explore risk factors for …

Randomized assignment of treatment excludes reverse causation and selection bias and, in
sufficiently large studies, effectively prevents confounding. Well-implemented blinding …

Successful recruitment is vital for any research study. Difficulties in recruitment are not
uncommon and can have important implications. This is particularly relevant to research …

Background: Clinical trials are the gold standard for advancing medical knowledge and
improving patient outcomes. For their success, an appropriately sized cohort is required …