Recommendations for evaluation of bladder and bowel function in pre-clinical spinal cord injury research

GM Holmes, CH Hubscher, A Krassioukov… - The journal of spinal …, 2020 - Taylor & Francis
Objective: In order to encourage the inclusion of bladder and bowel outcome measures in
preclinical spinal cord injury (SCI) research, this paper identifies and categorizes 1) …

Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty

DD Tu, YG Chung, ES Gil, A Seth, D Franck… - Biomaterials, 2013 - Elsevier
Acellular scaffolds derived from Bombyx mori silk fibroin were investigated for their ability to
support functional tissue regeneration in a porcine model of augmentation cystoplasty. Two …

The use of bi-layer silk fibroin scaffolds and small intestinal submucosa matrices to support bladder tissue regeneration in a rat model of spinal cord injury

YG Chung, K Algarrahi, D Franck, DD Tu, RM Adam… - Biomaterials, 2014 - Elsevier
Adverse side-effects associated with enterocystoplasty for neurogenic bladder
reconstruction have spawned the need for the development of alternative graft substitutes. Bi …

[HTML][HTML] Tissue engineering in pediatric urology–a critical appraisal

FM Schäfer, M Stehr - Innovative Surgical Sciences, 2018 - degruyter.com
Tissue engineering is defined as the combination of biomaterials and bioengineering
principles together with cell transplantation or directed growth of host cells to develop a …

[HTML][HTML] Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A2B pathway

C Doyle, V Cristofaro, BS Sack, SN Lukianov… - Scientific Reports, 2017 - nature.com
Neurogenic detrusor overactivity (NDO) is among the most challenging complications of
spinal cord injury (SCI). A recent report by us demonstrated an improvement in NDO in SCI …

[HTML][HTML] Inosine improves neurogenic detrusor overactivity following spinal cord injury

YG Chung, A Seth, C Doyle, D Franck, D Kim… - PLoS …, 2015 - journals.plos.org
Neurogenic detrusor overactivity and the associated loss of bladder control are among the
most challenging complications of spinal cord injury (SCI). Anticholinergic agents are the …

[HTML][HTML] Novel phenotype characterization utilizing electrical impedance myography signatures in murine spinal cord injury neurogenic bladder models

HHS Wang, H Thaker, A Bigger-Allen, JA Nagy… - Scientific Reports, 2023 - nature.com
Neurogenic bladder (NB) affects people of all ages. Electric impedance myography (EIM)
assesses localized muscle abnormalities. Here, we sought to investigate whether unique …

Effects of sacral neuromodulation on isolated urinary bladder function in a rat model of spinal cord injury

Ş Kumsar, U Keskin, A Akay, UT Bilgilisoy… - … : Technology at the …, 2015 - Elsevier
Introduction Sacral neuromodulation has been considered as an effective treatment option
for various types of chronic voiding dysfunction, but the mechanism of action has not been …

Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice

FA Kullmann, JM Beckel, B McDonnell… - Naunyn-Schmiedeberg's …, 2018 - Springer
Transient receptor potential cation channel subfamily M member 4 (TRPM4) has been
shown to play a key role in detrusor contractility under physiological conditions. In this study …

Effects of cathodal trans-spinal direct current stimulation on lower urinary tract function in normal and spinal cord injury mice with overactive bladder

Z Ahmed - Journal of neural engineering, 2017 - iopscience.iop.org
Objective. Lower urinary tract (LUT) dysfunction is a monumental problem affecting quality of
life following neurotrauma, such as spinal cord injury (SCI). Proper function of the bladder …