Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

M Marshall, FE Watt, TL Vincent… - Nature Reviews …, 2018 - nature.com
Osteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly
affected site. Patients with hand OA frequently report symptoms of pain, functional limitations …

Immune contributions to osteoarthritis

EBP Lopes, A Filiberti, SA Husain… - Current osteoporosis …, 2017 - Springer
Abstract Purpose of the Review Mounting evidence supports a role of low-grade
inflammation in the pathophysiology of osteoarthritis (OA). We review and discuss the role of …

Innate immune responses and osteoarthritis

E Kalaitzoglou, TM Griffin, MB Humphrey - Current Rheumatology Reports, 2017 - Springer
Abstract Purpose of the Review Osteoarthritis (OA) is a chronic, painful joint disease that
affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while …

Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis: a randomized trial

SR Kingsbury, P Tharmanathan, A Keding… - Annals of internal …, 2018 - acpjournals.org
Background: Synovitis is believed to play a role in producing symptoms in persons with
hand osteoarthritis, but data on slow-acting anti-inflammatory treatments are sparse …

A deep-learning framework for metacarpal-head cartilage-thickness estimation in ultrasound rheumatological images

MC Fiorentino, E Cipolletta, E Filippucci… - Computers in Biology …, 2022 - Elsevier
Objective Rheumatoid arthritis (RA) is a chronic disease characterized by erosive
symmetrical polyarthritis. Bone and cartilage are the main joint targets of this disease …

Cinnamic Aldehyde, the main monomer component of Cinnamon, exhibits anti‐inflammatory property in OA synovial fibroblasts via TLR4/MyD88 pathway

P Chen, J Zhou, A Ruan, L Zeng, J Liu… - Journal of Cellular and …, 2022 - Wiley Online Library
Cinnamon is a wildly used traditional Chinese herbal medicine for osteoarthritis (OA)
treatment, but the underlying mechanism remains ambiguous. The purpose of this study is to …

[HTML][HTML] TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate …

H Li, S Xie, Y Qi, H Li, R Zhang… - Experimental and …, 2018 - spandidos-publications.com
Osteoarthritis is a degenerative disease that often causes patients to experience joint pain
and deformity. It has been demonstrated that tumor necrosis factor (TNF)‑α is associated …

[HTML][HTML] Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial

MJM Minten, MM Leseman-Hoogenboom… - Osteoarthritis and …, 2018 - Elsevier
Objectives Low-dose radiation therapy (LDRT) is widely used as treatment for osteoarthritis
(OA) in some countries, while relatively unknown in others. Systematic literature review …

[HTML][HTML] Extraction and identification of synovial tissue-derived exosomes by different separation techniques

P Chen, A Ruan, J Zhou, L Huang, X Zhang… - Journal of orthopaedic …, 2020 - Springer
Objective The aim of this study is to compare the efficiency of different separation techniques
for extracting synovial tissue-derived exosomes. Methods The synovial tissue discarded …