Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …

Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2
significantly influences endothelial cells and induces pulmonary vascular endotheliopathy …

Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …

Background Increased osteoclast activity constitutes the primary etiology of excessive bone
erosion in postmenopausal osteoporosis. ERp57, otherwise referred to as protein disulfide …

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

Nitric oxide (NO) is a highly versatile gasotransmitter that has first been shown to regulate
cardiovascular function and then to exert tight control over a much broader range of …

Abstract Calcium ion (Ca 2+) dysregulation is one of the main causes of neuronal cell death
and brain damage after cerebral ischemia. During ischemic stroke, the ability of neurons to …

Lysosomal Ca2+ signaling is emerging as a crucial regulator of endothelial Ca2+ dynamics.
Ca2+ release from the acidic vesicles in response to extracellular stimulation is usually …

Capillaries are the smallest blood vessels (< 10 μm in diameter) in the body and their walls
are lined by endothelial cells. These microvessels play a crucial role in nutrient and gas …