The process of senescence (aging) is predominantly determined by the action of wild-type
genes. For most organisms, this does not reflect any adaptive function that senescence …

Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …

Cancer is a major cause of death worldwide, with an increasing number of cases being
reported annually. The elevated rate of mortality necessitates a global challenge to explore …

Chemoprevention of human cancer (s) is a viable option for cancer control, especially when
chemopreventive intervention is involved during the early stages of the carcinogenesis …

Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and
anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly …

Hallmarks of cancer and hallmarks of aging - PMC Back to Top Skip to main content NIH
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Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to
different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis …

Apoptosis is a tightly regulated cell suicide program that plays an essential role in the
maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in …

The problems with anticancer therapy are resistance and toxicity. From 3000 Cisplatin
derivatives tested as antitumor agents, most of them have been rejected, due to toxicity. The …

Identification and characterization of mutations that drive cancer evolution constitute a major
focus of cancer research. Consequently, dominant paradigms attribute the tumorigenic …