[HTML][HTML] T memory stem cells in health and disease
T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …
[HTML][HTML] Nano toolbox in immune modulation and nanovaccines
Despite the great success of vaccines over two centuries, the conventional strategy is based
on attenuated/altered microorganisms. However, this is not effective for all microbes and …
on attenuated/altered microorganisms. However, this is not effective for all microbes and …
[HTML][HTML] Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation
DP Ferreira, JG Silva, T Wyss, SAF Marraco… - Immunity, 2020 - cell.com
Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …
Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection
R Channappanavar, C Fett, J Zhao… - Journal of …, 2014 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV) caused an acute human
respiratory illness with high morbidity and mortality in 2002-2003. Several studies have …
respiratory illness with high morbidity and mortality in 2002-2003. Several studies have …
Generation of effector CD8+ T cells and their conversion to memory T cells
Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …
elucidate the mechanisms that govern the formation of memory T cells and their ability to …
[HTML][HTML] Suppression of Tcf1 by inflammatory cytokines facilitates effector CD8 T cell differentiation
The formation of central CD8 T cell memory in response to infection depends on the
transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive CD8 T cells but …
transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive CD8 T cells but …
The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens
RB Fulton, SE Hamilton, Y Xing, JA Best… - Nature …, 2015 - nature.com
The strength with which complexes of self peptide and major histocompatibility complex
(MHC) proteins are recognized by the T cell antigen receptor (TCR) dictates the …
(MHC) proteins are recognized by the T cell antigen receptor (TCR) dictates the …
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration
M Kurachi, J Kurachi, F Suenaga, T Tsukui… - Journal of experimental …, 2011 - rupress.org
Strength of inflammatory stimuli during the early expansion phase plays a crucial role in the
effector versus memory cell fate decision of CD8+ T cells. But it is not known how early …
effector versus memory cell fate decision of CD8+ T cells. But it is not known how early …
IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo
TCR ligation and co-stimulation induce cellular division; however, optimal accumulation of
effector CD8 T cells requires direct inflammatory signaling by signal 3 cytokines, such as IL …
effector CD8 T cells requires direct inflammatory signaling by signal 3 cytokines, such as IL …
[HTML][HTML] Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8+ T cells by enhancing T cell receptor signaling
CD8+ T cells confer host protection through T-cell-receptor (TCR)-mediated recognition of
foreign antigens presented by infected cells. Thus, generation of CD8+ T cell populations …
foreign antigens presented by infected cells. Thus, generation of CD8+ T cell populations …