Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

HA El-Mahdy, AM Mohamadin, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

[HTML][HTML] Paclitaxel and docetaxel resistance in prostate cancer: Molecular mechanisms and possible therapeutic strategies

M Hashemi, MA Zandieh, Y Talebi… - Biomedicine & …, 2023 - Elsevier
Prostate cancer is among most malignant tumors around the world and this urological tumor
can be developed as result of genomic mutations and their accumulation during progression …

Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities

SQ Sin, CD Mohan, RMWJ Goh, M You… - Cancer and Metastasis …, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers with a relatively high
cancer-related mortality. The uncontrolled proliferation of HCC consumes a significant …

[HTML][HTML] HMGA2 regulation by miRNAs in cancer: affecting cancer hallmarks and therapy response

M Hashemi, M Rashidi, K Hushmandi… - Pharmacological …, 2023 - Elsevier
High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …

The potential relevance of long non-coding RNAs in colorectal cancer pathogenesis and treatment: A review focus on signaling pathways

AS Doghish, MB Zaki, MG Eldeib, AF Radwan… - … -Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most frequent cancers in incidence and mortality.
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …

Gold nanostructure-mediated delivery of anti-cancer agents: Biomedical applications, reversing drug resistance, and stimuli-responsive nanocarriers

M Entezari, GGY Abad, B Sedghi, R Ettehadi… - Environmental …, 2023 - Elsevier
The application of nanoarchitectures in cancer therapy seems to be beneficial for the
delivery of anti-tumor drugs. In recent years, attempts have been made to reverse drug …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis

Z Zhou, Y Cao, Y Yang, S Wang, F Chen - Epigenetics, 2023 - Taylor & Francis
Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the
therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance …

Multi-omics analysis of DNA replication-associated primase polymerase (PRIMPOL) in pan-cancer: a potential target for prognosis and immune response

L Deng, A Thakur, J Peng, L Song, Z Li - European Journal of Medical …, 2023 - Springer
Background It is critical to understand the mechanisms of human cancers in order to develop
the effective anti-cancer therapeutic strategies. Recent studies indicated that primase …