[HTML][HTML] Bifurcation of signalling in human innate immune pathways to NF-kB and IRF family activation
A Kusiak, G Brady - Biochemical Pharmacology, 2022 - Elsevier
The human innate immune response can be activated through a wide range of stimuli. This
multi-faceted system can be triggered by a range of immunostimulants including pathogen …
multi-faceted system can be triggered by a range of immunostimulants including pathogen …
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …
[HTML][HTML] HTLV-1 infection and pathogenesis: new insights from cellular and animal models
G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …
models have provided invaluable contributions in the knowledge of viral infection …
[HTML][HTML] Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury
W Zhou, Z Zhong, D Lin, Z Liu, Q Zhang, H Xia… - Cell death & …, 2021 - nature.com
Ischemia-reperfusion injury (IRI) is an inevitable and serious clinical problem in donations
after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful …
after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful …
Integrative Analysis of Motor Neuron and Microglial Transcriptomes from SOD1G93A Mice Models Uncover Potential Drug Treatments for ALS
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neurons that mainly affects the
motor cortex, brainstem, and spinal cord. Under disease conditions, microglia could possess …
motor cortex, brainstem, and spinal cord. Under disease conditions, microglia could possess …
LncRNA XIST exacerbates oxygen-glucose deprivation/reoxygenation-induced cerebral injury through the miR-25-3p/TRAF3 axis
Y Li, JK Zhang, ZT Yu, JW Jiang, H Tang, GL Tu… - Molecular …, 2023 - Springer
Ischemic stroke causes lethal damage to the brain. Identifying key regulators of OGD/R-
induced cerebral injury is important for developing novel therapies for ischemic stroke …
induced cerebral injury is important for developing novel therapies for ischemic stroke …
[HTML][HTML] MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation
X Du, S Wang, X Liu, T He, X Lin, S Wu, D Wang… - Cancer Cell …, 2020 - Springer
Background Non-small cell lung cancer (NSCLC) includes lung adenocarcinoma (LUAD)
and lung squamous cell carcinoma (LUSC). MicroRNA (miRNA) plays an important role in …
and lung squamous cell carcinoma (LUSC). MicroRNA (miRNA) plays an important role in …
[HTML][HTML] NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer
Evolving understanding of head and neck squamous cell carcinoma (HNSCC) is leading to
more specific diagnostic disease classifications. Among HNSCC caused by the human …
more specific diagnostic disease classifications. Among HNSCC caused by the human …
[HTML][HTML] NF-κB and MicroRNA deregulation mediated by HTLV-1 tax and HBZ
S Fochi, V Ciminale, E Trabetti, U Bertazzoni… - Pathogens, 2019 - mdpi.com
The risk of developing adult T-cell leukemia/lymphoma (ATLL) in individuals infected with
human T-cell lymphotropic virus 1 (HTLV-1) is about 3–5%. The mechanisms by which the …
human T-cell lymphotropic virus 1 (HTLV-1) is about 3–5%. The mechanisms by which the …
[HTML][HTML] A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells
S Millen, L Meretuk, T Göttlicher, S Schmitt… - Retrovirology, 2020 - Springer
Background Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4+ T-
lymphocytes and evoques severe diseases, predominantly Adult T-Cell …
lymphocytes and evoques severe diseases, predominantly Adult T-Cell …