Rheumatoid arthritis is a chronic inflammatory synovitis that primarily involves peripheral
diarthrodial joints. Immunohistologic analysis of diseased synovium has shown a spectrum …

While studying the αβ T cell receptor repertoire in rheumatoid arthritis (RA) patients, we
found that the frequency of Vβ14+ T cells was significantly higher in the synovial fluid of …

Many autoimmune disorders share two common features, dysregulation of the immune
system and stress pathways. Two stress pathways, the hypothalamic-pituitaryadrenal (HPA) …

One of the hallmarks in rheumatoid arthritis (RA) is the intense activation of the monocyte-
macrophage system. In the present investigation, the modulation of blood monocyte …

The fate in culture of the T cell growth factor (TCGF), which is required for continued growth
of human cultured T cells (CTC) in vitro, was studied. TCGF activity was stable for 7 days at …

The antirheumatic effects of lymphocyte depletion in rheumatoid arthritis were confirmed in a
randomized, double‐blind trial. Six patients assigned to lymphapheresis demonstrated …

Objective To determine the efficacy and safety of filtration leukocytapheresis (LCP) for the
treatment of rheumatoid arthritis (RA). Methods Twenty‐five patients with drug‐resistant RA …

Although substantial evidence suggests that synovial T lymphocytes are critical in the
pathogenesis of rheumatoid arthritis (RA), little is known regarding their antigenic …

Interest in the possibility of growing large numbers of antigen-reactive human T lymphocytes
led to a thorough study of the production of T-cell growth factor (s) that allow the continued …

Objectives. To evaluate the efficacy of filtration leucocytapheresis (LCP) for rheumatoid
arthritis (RA). Methods. LCP was carried out three times, with 1 week separating each …