Lipids and lipoproteins, their metabolism, and their transport are essential contributing
factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration …

Pathological tissue remodeling is closely associated with the occurrence and aggravation of
various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin …

Rare coding mutations cause∼ 45% of congenital heart disease (CHD). Noncoding
mutations that perturb cis-regulatory elements (CREs) likely contribute to the remaining …

Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of
the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of …

Aims Heart failure is a condition with high mortality rates, and there is a lack of therapies that
directly target maladaptive changes in the extracellular matrix (ECM), such as fibrosis. We …

Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …

The chondroitin sulfate proteoglycan versican is important for embryonic development and
several human disorders. The versican V1 splice isoform is widely expressed and cleaved …

Recent genome-wide association studies have successfully identified associations between
genetic variants and simple cardiac morphological parameters derived from cardiac …

Pericytes are multipotent mesenchymal stromal cells playing an active role in angiogenesis,
vessel stabilisation, maturation, remodelling, blood flow regulation and are able to trans …

Abdominal aortic aneurysms (AAAs) are characterized histopathologically by compromised
elastic fiber integrity, lost smooth muscle cells or their function, and remodeled collagen. We …