Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

The cardiovascular system provides blood supply throughout the body and as such is
perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with …

Vascular endothelial protein tyrosine phosphatase (VE‐PTP) influences endothelial barrier
function by regulating the activation of tyrosine kinase receptor Tie2. We determined …

Shear stress exerted by the blood stream modulates endothelial functions through altering
gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted …

Background The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely
regulated by the blood pressure. To date, however, the molecular identity through which JG …

Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity,
with 47,000 described species and an estimated 150,000 species in existence. Evolving …

Physical forces exert profound effects on cells affecting fate, function, and response to
stressors. In the case of the endothelium, the layer that resides in the inner surface of blood …

Endothelial dysfunction is a key player in advancing vascular pathology in pulmonary
arterial hypertension (PAH), a disease essentially characterized by intense remodeling of …

In intrapulmonary arteries (IPAs), mechanical forces due to blood flow control vessel tone,
and these forces change during pulmonary hypertension (PH). Piezo1, a stretch-activated …

Mechanical forces are translated into biochemical stimuli by mechanotransduction channels,
such as the mechanically activated cation channel Piezo2. Lung Piezo2 expression has …