PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine
protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian …

Dietary restriction (DR) has the remarkable ability to extend lifespan and healthspan. A
variety of DR regimens have been described in species ranging from yeast to mammals …

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …

Understanding the complexity of aging is of utmost importance. This can now be addressed
by the novel and powerful approach of metabolomics. However, to date, only a few …

More than 70 years after its initial report, caloric restriction stands strong as the most
consistent non-pharmacological intervention increasing lifespan and protecting against …

Chronic stress can affect human health through a myriad of behavioral and biochemical
pathways. This review focuses on some key hormonal and metabolic pathways that appear …

The renin-angiotensin system plays a role in the etiology of hypertension and the
pathophysiology of cardiac and renal diseases in humans. Ang II is the central product of …

Caloric restriction (CR) and down‐regulation of the insulin/IGF pathway are the most robust
interventions known to increase longevity in lower organisms. However, little is known about …

Extensive studies during the past four decades have identified important roles for lysine
acetylation in the regulation of nuclear transcription. Recent proteomic analyses on protein …

Background Dietary effects on the gut microbiome play key roles in the pathophysiology of
inflammatory disorders, metabolic syndrome, obesity, and behavioral dysregulation. Often …