Physical exercise and fitness have been proposed as potential factors that promote healthy
cognitive aging. Support for this hypothesis has come from cross sectional, longitudinal, and …

Ghrelin is a peptide hormone produced and secreted in the stomach. Numerous studies
over the past decade demonstrate its importance in food intake, body-weight regulation and …

Caloric restriction (CR) has been widely accepted as a mechanism explaining increased
lifespan (LS) in organisms subjected to dietary restriction (DR), but recent studies …

Balancing the quantity and quality of dietary protein relative to other nutrients is a key
determinant of evolutionary fitness. A theoretical framework for defining a balanced diet …

Invertebrate animals have been used as medicinals for 4,000 years and have served as
models for research and teaching since the late 1800s. Interest in invertebrate models has …

Human syndromes and mouse mutants that exhibit accelerated but bona fide aging in
multiple organs and tissues have been invaluable for the identification of nine denominators …

Blueberry possesses greater antioxidant capacity than most other fruits and vegetables. The
present study investigated the lifespan-prolonging activity of blueberry extracts in fruit flies …

The gut is the primary interface between an animal and food, but how it adapts to qualitative
dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes …

Feeding behavior, metabolism and circadian clocks are interlinked. Calorie restriction (CR)
is a feeding paradigm known to extend longevity. We found that CR significantly affected the …

Myricetin is a naturally occurring flavonol found in many plant based food sources. It
increases the lifespan of Caenorhabditis elegans, but the molecular mechanisms are not yet …