Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in developing cardiovascular diseases such as hypertension, atrial …

Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

Abstract Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …

Background Mendelian randomization (MR) is being increasingly used to strengthen causal
inference in observational studies. Availability of summary data of genetic associations for a …

Mendelian randomization (MR) uses genetic data to probe questions of causality in
epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent …

Клинические рекомендации уже давно вошли в число рабочих инструментов
современного врача, помогая ему быстро ориентироваться в наиболее эффективных …

Background Two-sample summary-data Mendelian randomization (MR) incorporating
multiple genetic variants within a meta-analysis framework is a popular technique for …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …

Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …