The hereditary Long QT syndrome (LQTS) is a genetic channelopathy with variable
penetrance that is associated with increased propensity for polymorphic ventricular …

The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Dilated cardiomyopathy is characterised by left ventricular dilation that is associated with
systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can …

In children with structurally normal hearts, the mechanisms of arrhythmias are usually the
same as in the adult patient. Some arrhythmias are particularly associated with young age …

Aims Congenital long QT syndromes (LQTSs) are associated with prolonged ventricular
repolarization and sudden cardiac death. Limitations to existing clinical therapeutic …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

The Ca2+ release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction
coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to …

Sudden cardiac death is among the most common causes of cardiovascular death in
developed countries. The majority of sudden cardiac deaths are caused by acute ventricular …

Background—Genetic testing for long-QT syndrome (LQTS) has diagnostic, prognostic, and
therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility …

To identify genetic factors influencing cardiac conduction, we carried out a genome-wide
association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified …