Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that
deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired …

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

The Hippo signaling pathway is highly conserved from Drosophila melanogaster to
mammals and plays a crucial role in organ size control, tissue regeneration, and tumor …

Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma,
myeloma and other heterogeneous tumors that seriously threaten human life and health …

Pancreatic ductal adenocarcinoma continues to be a lethal disease, for which efficient
treatment options are very limited. Increasing efforts have been taken to understand how to …

Metformin, a widely prescribed drug for treating type II diabetes, is one of the most
extensively recognized metabolic modulators which has shown an important anti-cancer …

Background Metformin has been reported to function as the anti-tumor inhibiting the growth
of different types of cancers, including bladder cancer. But there are few reports on the roles …

Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital
role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated …

This retrospective cohort study investigated whether metformin may reduce gastric cancer
risk by using the reimbursement databases of the Taiwan's National Health Insurance …

Background: Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide
with a very high recurrence rate and very dismal prognosis. Diagnosis and treatment in HCC …