Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

Vitamin A (VA) deficiency causes over 600000 deaths per year, mostly of young children or
pregnant women. Populations prone to VA deficiency obtain about 82% of their VA from …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …

Epigenetic modifications, of which DNA methylation is the best studied one, can convey
environmental information through generations via parental germ lines. Past studies have …

Here we investigated a pharmacological approach to inhibit spermatogenesis in the mouse
model by manipulating retinoid signaling using low doses of the pan-retinoic acid receptor …

The East African Shorthorn Zebu (EASZ) cattle are ancient hybrid between Asian zebu×
African taurine cattle preferred by local farmers due to their adaptability to the African …

Retinoic acid (RA), an active vitamin A derivative, is essential for mammalian
spermatogenesis. Genetic studies have revealed that oxidation of vitamin A to retinal by …

Spermatogenesis is a highly regulated process of germ cell proliferation and differentiation,
starting from spermatogonia to spermatocytes and giving rise to spermatids, the future …

In mammals, dietary vitamin A intake is essential for the maintenance of adequate retinoid
(vitamin A and metabolites) supply of tissues and organs. Retinoids are taken up from …

Retinoic acid receptor alpha (RARA), a nuclear receptor protein, has been validated as a
target for male contraception by gene knockout studies and also pharmacologically using a …