Dynamic EMT: a multi‐tool for tumor progression
S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
Targeting TGF-β signal transduction for fibrosis and cancer therapy
D Peng, M Fu, M Wang, Y Wei, X Wei - Molecular cancer, 2022 - Springer
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement
in early embryonic development and organogenesis, immune supervision, tissue repair, and …
in early embryonic development and organogenesis, immune supervision, tissue repair, and …
TGFβ biology in cancer progression and immunotherapy
R Derynck, SJ Turley, RJ Akhurst - Nature Reviews Clinical Oncology, 2021 - nature.com
TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …
their epithelial antiproliferative response and benefit from increased TGFβ expression and …
Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
X Shi, J Yang, S Deng, H Xu, D Wu, Q Zeng… - Journal of Hematology & …, 2022 - Springer
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
[HTML][HTML] FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …
immune homeostasis and inhibit immune responses in various diseases, including cancer …
[HTML][HTML] Clinical development of therapies targeting TGFβ: current knowledge and future perspectives
D Ciardiello, E Elez, J Tabernero, J Seoane - Annals of Oncology, 2020 - Elsevier
Transforming growth factor beta (TGFβ) is a pleiotropic cytokine that plays a key role in both
physiologic and pathologic conditions, including cancer. Importantly, TGFβ can exhibit both …
physiologic and pathologic conditions, including cancer. Importantly, TGFβ can exhibit both …
Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …
The anti-cancer effects and mechanisms of lactic acid bacteria exopolysaccharides in vitro: A review
J Wu, Y Zhang, L Ye, C Wang - Carbohydrate polymers, 2021 - Elsevier
Probiotic lactic acid bacteria (LAB) are a particular group of gram-positive bacteria that are
usually involved in natural ferments and widely used in food manufacture industry. Most of …
usually involved in natural ferments and widely used in food manufacture industry. Most of …