Benzannulation strategies for the synthesis of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines

A Banerjee, S Kundu, A Bhattacharyya… - Organic Chemistry …, 2021 - pubs.rsc.org
Nitrogen-containing π-excessive aromatic heterocycles, in particular, carbazoles,
indolocarbazoles, benzocarbazoles, and carbolines have been considered the fundamental …

Recent advances on synthesis and biological activities of aurones

G Sui, T Li, B Zhang, R Wang, H Hao, W Zhou - Bioorganic & Medicinal …, 2021 - Elsevier
Aurones are naturally occurring structural isomerides of flavones that have diverse
bioactivities including antiviral, antibacterial, antifungal, anti-inflammatory, antitumor …

[HTML][HTML] Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

SM Xu, L Wei, C Shen, L Xiao, HY Tao… - Nature …, 2019 - nature.com
Enantiomerically enriched indole-containing heterocycles play a vital role in bioscience,
medicine, and chemistry. As one of the most attractive subtypes of indole alkaloids, highly …

[HTML][HTML] 1, 3, 4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships

S Nayak, SL Gaonkar, EA Musad… - Journal of Saudi Chemical …, 2021 - Elsevier
Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …

Recent advances on the synthesis and application of tetrahydro-γ-carbolines

H Mei, K Aradi, L Kiss, J Han - Chinese Chemical Letters, 2023 - Elsevier
Tetrahydro-γ-carbolines (THγ Cs) constitute one of the most important subtypes of indole
alkaloids. In addition to being substructures of natural products, these structural motifs and …

Visible-light-irradiated cascade reaction of indole-tethered alkenes to access tetracyclic tetrahydro-γ-carbolines

H Mei, A Liu, J He, Y Yu, J Han - Organic Letters, 2022 - ACS Publications
A series of indole-derived alkenes have been designed and applied in a photocatalytic
cascade reaction with bromodifluoroacetate esters, affording an unknown type of tetracyclic …

Carboline regioisomers based on unified synthetic approaches

ASM Arshad, MN Mordi - Advanced Synthesis & Catalysis, 2023 - Wiley Online Library
Carbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and
bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ …

[HTML][HTML] Modular assembly of indole alkaloids enabled by multicomponent reaction

J Li, Z Lai, W Zhang, L Zeng, S Cui - Nature Communications, 2023 - nature.com
Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in
pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly …

Rapid Access to Fused Tetracyclic N-Heterocycles via Amino-to-Alkyl 1,5-Palladium Migration Coupled with Intramolecular C(sp3)–C(sp2) Coupling

D Chen, J Li, X Zhang, G Liu, X Wang, Y Liu, X Liu… - Organic …, 2023 - ACS Publications
An unprecedented route for the preparation of fused tetracyclic N-heterocycles is presented
through the palladium-catalyzed cyclization of isocyanides with alkyne-tethered aryl iodides …

Hydroxamic acid hybrids as the potential anticancer agents: An Overview

W Liu, Y Liang, X Si - European Journal of Medicinal Chemistry, 2020 - Elsevier
Hydroxamic acid derivatives are potential histone deacetylase inhibitors, and several
hydroxamic acid-based histone deacetylase inhibitors have already been used clinically as …