[HTML][HTML] Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

TI Janjua, Y Cao, F Kleitz, M Linden, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They
have been used in many different biomedical fields including diagnosis, biosensing and …

[HTML][HTML] Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

Current advances in multifunctional nanocarriers based on marine polysaccharides for colon delivery of food polyphenols

S Tie, M Tan - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Inflammatory bowel disease (IBD) has been considered as a chronic disease that is difficult
to cure and needs lifelong treatment. Marine polysaccharides with good biocompatibility and …

Recent advances in oral and transdermal protein delivery systems

Y Yang, R Zhou, Y Wang, Y Zhang, J Yu… - Angewandte …, 2023 - Wiley Online Library
Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …

Mucus penetration of surface-engineered nanoparticles in various pH microenvironments

Y Guo, Y Ma, X Chen, M Li, X Ma, G Cheng, C Xue… - ACS …, 2023 - ACS Publications
The penetration behavior of nanoparticles in mucous depends on physicochemical
properties of the nanoparticles and the mucus microenvironment, due to particle–mucin …

Bioinspired pH-responsive microalgal hydrogels for oral insulin delivery with both hypoglycemic and insulin sensitizing effects

C Ren, D Zhong, Y Qi, C Liu, X Liu, S Chen, S Yan… - ACS …, 2023 - ACS Publications
The oral form of insulin is more convenient and has better patient compliance than
subcutaneous or intravenous insulin. Current oral insulin preparations, however, cannot …

[HTML][HTML] Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

Y Li, W Zhang, R Zhao, X Zhang - Bioactive Materials, 2022 - Elsevier
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …

Nanocarriers transport across the gastrointestinal barriers: the contribution to oral bioavailability via blood circulation and lymphatic pathway

D Wang, Q Jiang, Z Dong, T Meng, F Hu, J Wang… - Advanced Drug Delivery …, 2023 - Elsevier
Oral administration is the preferred route of drug delivery in clinical practice due to its
noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal …

[HTML][HTML] Versatile oral insulin delivery nanosystems: from materials to nanostructures

M Wang, C Wang, S Ren, J Pan, Y Wang… - International Journal of …, 2022 - mdpi.com
Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading
to failure of blood glucose regulation. Diabetes patients usually need frequent insulin …

Oral Delivery of Protein Drugs via Lysine Polymer‐Based Nanoparticle Platforms

S Han, P Xin, Q Guo, Z Cao… - Advanced Healthcare …, 2023 - Wiley Online Library
Oral delivery of proteins has opened a new perspective for the treatment of different
diseases. However, advances of oral protein formulation are usually hindered by protein …