Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets

T Wang, C Gross, AA Desai… - … of Physiology-Lung …, 2017 - journals.physiology.org
Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …

Less invasive surfactant administration: a word of caution

D De Luca, S Shankar-Aguilera… - The Lancet Child & …, 2020 - thelancet.com
Surfactant is a cornerstone of neonatal critical care, and the presumed less (or minimally)
invasive techniques for its administration have been proposed to reduce invasiveness of …

De Novo Design of Activatable Photoacoustic/Fluorescent Probes for Imaging Acute Lung Injury In Vivo

XP Fan, J Huang, TB Ren, L Yuan… - Analytical …, 2022 - ACS Publications
Effective monitoring of the physiological progression of acute lung injury (ALI) in real time is
crucial for early theranostics to reduce its high mortality. In particular, activatable …

[HTML][HTML] Lung imaging: how to get better look inside the lung

L Ball, V Vercesi, F Costantino… - Annals of …, 2017 - ncbi.nlm.nih.gov
In the last years, imaging has played a key role in the diagnosis and monitoring and critical
illness, including acute respiratory distress syndrome (ARDS). Chest X-ray (CXR) and …

[HTML][HTML] Artificial intelligence-assisted terahertz imaging for rapid and label-free identification of efficient light formula in laser therapy

J Shi, Z Guo, H Chen, Z Xiao, H Bai, X Li, P Niu, J Yao - Biosensors, 2022 - mdpi.com
Photodynamic therapy (PDT) is considered a promising noninvasive therapeutic strategy in
biomedicine, especially by utilizing low-level laser therapy (LLLT) in visible and near …

[HTML][HTML] A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase A2 Activity Significantly Protects against Lung Injury in a Mouse Model of Ventilator Induced Lung Injury …

AB Fisher, C Dodia, S Chatterjee - Antioxidants, 2021 - mdpi.com
Ventilator induced lung injury (VILI) is a lung injury syndrome associated with mechanical
ventilation, most frequently for treatment of Acute Lung Injury (ALI), and generally secondary …

Protective role of p120‐catenin on mitochondria by inhibiting NLRP3 in ventilator‐induced lung injury

G Liu, C Gu, M Liu, H Liu, D Wang… - Journal of Cellular …, 2019 - Wiley Online Library
Mitochondria supply energy to maintain the integrity of cell junctions. NLRP3, as the core
component of the inflammatory response, is crucial in mechanical stretching. Mechanical …

Punicalagin suppresses inflammation in ventilator‐induced lung injury through protease‐activated receptor‐2 inhibition‐induced inhibition of NLR family pyrin domain …

W Zhang, Q Zhu - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Punicalagin is recorded to be a potent anti‐inflammatory drug, while its effect on
inflammation existing in ventilator‐induced lung injury (VILI) requires further verification …

Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis

J Guo, WD Hardie, ZI Cleveland… - Journal of Applied …, 2019 - journals.physiology.org
To longitudinally monitor progressive fibrosis in the transforming growth factor-α (TGF-α)
transgenic mouse model of lung fibrosis, we used retrospective self-gating ultrashort echo …

Reproducibility of 19F‐MR ventilation imaging in healthy volunteers

BJ Pippard, MA Neal, AM Maunder… - Magnetic …, 2021 - Wiley Online Library
Purpose To assess the reproducibility of percentage ventilated lung volume (% VV)
measurements in healthy volunteers acquired by fluorine (19F)‐MRI of inhaled …