HIV‐Related Immune Activation and Inflammation: Current Understanding and Strategies

T Lv, W Cao, T Li - Journal of immunology research, 2021 - Wiley Online Library
Although antiretroviral therapy effectively controls human immunodeficiency virus (HIV)
replication, a residual chronic immune activation/inflammation persists throughout the …

Microbial infections are a risk factor for neurodegenerative diseases

SK Lotz, BM Blackhurst, KL Reagin… - Frontiers in Cellular …, 2021 - frontiersin.org
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …

Bio-indicators in cadmium toxicity: Role of HSP27 and HSP70

ME Taghavizadeh Yazdi, MS Amiri… - … Science and Pollution …, 2021 - Springer
Heat shock proteins (HSPs) are a family of proteins that are expressed by cells in reply to
stressors. The changes in concentration of HSPs could be utilized as a bio-indicator of …

Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways

S Phuagkhaopong, D Ospondpant, T Kasemsuk… - Neurotoxicology, 2017 - Elsevier
Chronic exposure to cadmium has been linked to brain cancers, learning disabilities and
memory deficits. Previous studies of cadmium toxicity in the central nervous system report …

HIV-associated neurotoxicity and cognitive decline: Therapeutic implications

DR Wallace - Pharmacology & Therapeutics, 2022 - Elsevier
As our understanding of changes to the neurological system has improved, it has become
clear that patients who have contracted human immunodeficiency virus type 1 (HIV-1) can …

Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases

YS Li, HC Ren, JH Cao - International Immunopharmacology, 2022 - Elsevier
Abstract Interleukin-6 (IL-6) is a highly pleiotropic glycoprotein factor that can modulate
innate and adaptive immunity as well as various aspects of metabolism, including glycolysis …

Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND

J Marino, ME Maubert, AR Mele, C Spector… - Cellular and Molecular …, 2020 - Springer
Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) is a potent
mediator involved in the development of HIV-1-associated neurocognitive disorders …

Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer's disease?

T Fulop, JM Witkowski, A Larbi, A Khalil… - Journal of …, 2019 - Springer
HIV infection in the combination antiretroviral therapy (cART) era has become a chronic
disease with a life expectancy almost identical to those free from this infection …

Humanized mice for studies of HIV-1 persistence and elimination

C Zhang, LA Zaman, LY Poluektova, S Gorantla… - Pathogens, 2023 - mdpi.com
A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is
the persistence of latent viral infections in the cells and tissue compartments of an infected …

Targeting infectious agents as a therapeutic strategy in Alzheimer's disease

T Fülöp, U Munawara, A Larbi, M Desroches… - CNS drugs, 2020 - Springer
Alzheimer's disease (AD) is the most prevalent dementia in the world. Its cause (s) are
presently largely unknown. The most common explanation for AD, now, is the amyloid …