Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …

Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during
aging but are functionally impaired. However, the role of HSC-intrinsic and-extrinsic aging …

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead
to increased healthspan. Emerging evidence suggests a crucial role for signalling from the …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Emerging evidence indicates that the accretion of senescent cells is linked to metabolic
disorders. However, the underlying mechanisms and metabolic consequences of cellular …

Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …