The segmental premature aging disease Hutchinson-Gilford Progeria (HGPS) is caused by
a truncated and farnesylated form of Lamin A. In a mouse model for HGPS, a similar Lamin A …

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused
by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous …

Organ‐on‐a‐chip platforms seek to recapitulate the complex microenvironment of human
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …

Hutchinson-Gilford progeria syndrome is a rare, segmental premature aging syndrome of
accelerated atherosclerosis and early death from myocardial infarction or stroke. This study …

Hutchinson-Gilford progeria syndrome (HGPS) is a sporadic, autosomal dominant disorder
characterized by premature and accelerated aging symptoms leading to death at the mean …

Human geneticists have shown that some progeroid syndromes are caused by mutations
that interfere with the conversion of farnesyl-prelamin A to mature lamin A. For example …

In eukaryotes, the function of the cell's nucleus has primarily been considered to be the
repository for the organism's genome. However, this rather simplistic view is undergoing a …

Importance Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare disorder
associated with premature death due to cardiovascular events during the second decade of …

Mandibuloacral dysplasia syndromes are mainly due to recessive LMNA or ZMPSTE24
mutations, with cardinal nuclear morphological abnormalities and dysfunction. We report five …

Vascular aging plays a central role in health problems and mortality in older people. Apart
from the impact of several classical cardiovascular risk factors on the vasculature …