The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Macrophages are extremely heterogeneous and plastic cells with an important role not only
in physiological conditions, but also during inflammation (both for initiation and resolution) …

Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for
cancer treatment. BAY 11–7085 (BAY), which is a well-known IκBα inhibitor, suppressed …

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

Immune-based interventions are promising strategies to achieve long-term cancer-free
survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy …

The use of synthetic drugs has increased over the recent years, but plant-based drugs are
more suitable in terms of least side effects. Since ancient times mankind has been …

Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …