Transcriptional response networks for elucidating mechanisms of action of multitargeted agents
Highlights•Elucidation of a compound's target mechanisms is key to predicting its phenotypic
effects.•Computational network pharmacology models provide hypotheses on multi-target …
effects.•Computational network pharmacology models provide hypotheses on multi-target …
[HTML][HTML] Gossypol inhibits electron transport and stimulates ROS generation in Yarrowia lipolytica mitochondria
AY Arinbasarova, AG Medentsev… - The Open Biochemistry …, 2012 - ncbi.nlm.nih.gov
This work studied the effect of gossypol on the mitochondrial respiratory chain of Yarrowia
lipolytica. The compound was shown to inhibit mitochondrial electron transfer and stimulate …
lipolytica. The compound was shown to inhibit mitochondrial electron transfer and stimulate …
Gossypol-embedded casein nanoparticles for potential targeting of ovarian cancer: formulation, characterization, and anticancer activity
Background The present study intends to investigate the ability of gossypol-loaded casein
nanoparticles (gossypol-loaded CAS NPs) for the treatment of ovarian cancer. The key …
nanoparticles (gossypol-loaded CAS NPs) for the treatment of ovarian cancer. The key …
Gossypol from Gossypium spp. Inhibits Helicobacter pylori Clinical Strains and Urease Enzyme Activity: Bioactivity and Safety Assessments
M Šudomová, STS Hassan - Scientia Pharmaceutica, 2022 - mdpi.com
This study investigates the inhibitory activities of gossypol, a natural polyphenolic compound
from Gossypium spp., against Helicobacter pylori (HP) clinical strains and a urease enzyme …
from Gossypium spp., against Helicobacter pylori (HP) clinical strains and a urease enzyme …
Mediation of multiple pathways regulating cell proliferation, migration, and apoptosis in the human malignant glioma cell line U87MG via unphosphorylated STAT1
H Ju, X Li, H Li, X Wang, H Wang, Y Li, C Dou… - Journal of …, 2013 - thejns.org
Object Signal transducer and activator of transcription 1 (STAT1) is thought to be a tumor
suppressor protein. The authors investigated the expression and role of STAT1 in …
suppressor protein. The authors investigated the expression and role of STAT1 in …
[PDF][PDF] Gossypol acetic acid induces apoptosis in RAW264. 7 cells via a caspase-dependent mitochondrial signaling pathway
S Deng, H Yuan, J Yi, Y Lu, Q Wei… - Journal of …, 2013 - synapse.koreamed.org
To investigate the effects of gossypol acetic acid (GA) on proliferation and apoptosis of the
macrophage cell line RAW264. 7 and further understand the possible underlying …
macrophage cell line RAW264. 7 and further understand the possible underlying …
Gossypol-Capped Mitoxantrone-Loaded Mesoporous SiO2 NPs for the Cooperative Controlled Release of Two Anti-Cancer Drugs
V Heleg-Shabtai, R Aizen, E Sharon… - … Applied Materials & …, 2016 - ACS Publications
Mesoporous SiO2 nanoparticles, MP-SiO2 NPs, are functionalized with the boronic acid
ligand units. The pores of the MP-SiO2 NPs are loaded with the anticancer drug …
ligand units. The pores of the MP-SiO2 NPs are loaded with the anticancer drug …
Keap1 Negatively Regulates Transcription of Three Counter-Defense Genes and Susceptibility to Plant Toxin Gossypol in Helicoverpa armigera
X Xie, Q Wang, Z Deng, S Gu, G Liang, X Li - Insects, 2024 - mdpi.com
Simple Summary The Keap1-Nrf2-ARE signaling pathway has been suggested to induce
the expressions of antioxidant and counter-defense genes, and aid cells in xenobiotic and …
the expressions of antioxidant and counter-defense genes, and aid cells in xenobiotic and …
Antiviral activity and mechanism of gossypols: effects of the O 2˙− production rate and the chirality
B Zhang, Y Liu, Z Wang, Y Li, Q Wang - RSC advances, 2017 - pubs.rsc.org
(−)-Gossypol displayed an obviously higher antiviral activity against the tobacco mosaic
virus (TMV) than (+)-gossypol, whereas the anti-TMV activity of (−)-gossypol Schiff bases is …
virus (TMV) than (+)-gossypol, whereas the anti-TMV activity of (−)-gossypol Schiff bases is …